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Sunday, February 13, 2005

New York –”Buy cheap Viagra through us – no prescription required!” Anyone with an active email account will recognize lines like this one. According to some reports, unsolicited advertisements (spam) for Viagra and similar drugs account for one in four spam messages.

Ever since pharmaceutical giant Pfizer promised to cure erectile dysfunction once and for all with its blue pills containing the drug sildenafil citrate, spammers have tried to tap into male anxiety by offering prescription-free sales of unapproved “generic” Viagra and clones such as Cialis soft tabs. Legislation like the U.S. CAN-SPAM act has done little to stem the tide of email advertising the products.

Now Pfizer has entered a pledge with Microsoft Corporation, the world’s largest software company, to address the problem. The joint effort will focus on lawsuits against spammers as well as the companies they advertise. “Pfizer is joining with Microsoft on these actions as part of our shared pledge to reduce the sale of these products and to fight the senders of unsolicited e-mail that overwhelms people’s inboxes,” said Jeff Kindler, executive vice president at Pfizer.

Microsoft has filed civil actions against spammers advertising the websites CanadianPharmacy and E-Pharmacy Direct. Pfizer has filed lawsuits against the two companies, and has taken actions against websites which use the word “Viagra” in their domain names. Sales of controlled drugs from Canadian pharmacies to the United States are illegal, but most drugs sold in Canada have nevertheless undergone testing by the U.S. Food and Drug Administration. This is not the case for many of the Viagra clones sold by Internet companies and manufactured in countries like China and India. While it was not clear that CanadianPharmacy was actually shipping drugs from Canada, Pfizer’s general counsel, Beth Levine, claimed that the company filled orders using a call center in Montreal, reported the Toronto Star.

For Microsoft’s part, they allege that the joint effort with Pfizer is part of their “multi-pronged attack on the barrage of spam.” As the creator of the popular email program Outlook, Microsoft has been criticized in the past for the product’s spam filtering process. Recently, Microsoft added anti-spam measures to its popular Exchange server. Exchange 2003 now includes support for accessing so-called real-time block lists, or RTBLs. An RTBL is a list of the IP addresses maintained by a third party; the addresses on the list are those of mailservers thought to have sent spam recently. Exchange 2003 can query the list for each message it receives.

Monday, April 6, 2009

Over 1,600 volunteers registered to help build approximately 65,000 of the 500,000 sandbags to create dikes 20.5 feet (6.2 meters) high to protect the City of Winnipeg, Manitoba in the war against the Red River of the North flood.

700 volunteers answered at the rural municipality of St. Andrews alone. Once sandbags are filled for West St. Paul, St. Andrews, and Selkirk, then frozen culverts must be cleared.

The height of the river is expected to be Thursday, and predictions are that it will be less than Flood of the Century of 1997. There is no precipitation in the forecast, and snow in the province should be melted by the end of the week.

“The fear right now is we have to get that ice out of the river. The Amphibex [Excavators] are still working and breaking the ice apart, and everyday we buy with the warm weather and the current, it is thinning the ice down a bit, so when it does start to move, the better chance it’ll move right out into the lake,” said Paul Guyder, the emergency coordinator for the RMs of St. Andrews and St. Clements.

“I feel that we’ve done everything humanly possible to get ready,” said Gary Doer, Premier of Manitoba, “But … there are fallibilities with human behaviour. We can take every preventative measure as human beings possible and we can still get Mother Nature proving again she is superior.”

Communities with ring diking will partially or fully close their dikes at the beginning of the week. Provincial officials are considering opening the Red River Floodway gates around mid-week before ice is fully melted.

Ice jams could cause flooding within the city, however opening the gates could spare neighbourhood flooding when the river rises to the estimated 6.3 meters (20.7 feet) height. The province does have back up plans for dealing with ice jams within the city if they do occur. The unpredictability of ice jams and the ensuing water level rise may cause neighbourhood flooding. The city is raising dikes where the river has jammed with ice in the past such as on tight curves and past bridges. Likewise there are excavators and backhoes positioned at these points.

Vulnerable neighbourhoods on the river banks have been reinforced with sandbag dikes at vulnerable areas from the massive volunteer effort over the weekend. Guyader feels no more extra volunteers are needed, however volunteers are still being asked to leave their names and number in case of unpredicted need. Existing personnel will assess roads, and help with clean up.

Approximately 400 of the 800 people who evacuated the Roseau River Anishinabe First Nation have returned to their homes.

Former Premier, Dufferin Roblin, brought forward the floodway as a protection for Winnipeg residents and economy following the 1950 Red River Flood. The Red River floodway, “Duff’s Ditch” was finally finished in 1968, and its floodway gates have been opened 20 times saving Winnipeg from an estimated CA$10 billion in damages. The floodway expansion began in 2005 at a price of $665 million.

Polish and Chinese experts have come to survey the Red River Floodway, and Dennis Walaker, mayor of Fargo, North Dakota recognises the need for Red River flood defences down river. “Every town that you drive by from the Canadian line up to Winnipeg is either elevated or ring-diked,” said Walaker.

Tuesday, February 19, 2008

While nearly all cover of the 2008 Presidential election has focused on the Democratic and Republican candidates, the race for the White House also includes independents and third party candidates. These parties represent a variety of views that may not be acknowledged by the major party platforms.

As a non-partisan news source, Wikinews has impartially reached out to these candidates, throughout the campaign. The most recent of our interviews is North Carolina, Tom Millican, an independent corporate manager and Vietnam veteran.

Thursday, December 18, 2008

A team of eight transplant surgeons in Cleveland Clinic in Ohio, USA, led by reconstructive surgeon Dr. Maria Siemionow, age 58, have successfully performed the first almost total face transplant in the US, and the fourth globally, on a woman so horribly disfigured due to trauma, that cost her an eye. Two weeks ago Dr. Siemionow, in a 23-hour marathon surgery, replaced 80 percent of her face, by transplanting or grafting bone, nerve, blood vessels, muscles and skin harvested from a female donor’s cadaver.

The Clinic surgeons, in Wednesday’s news conference, described the details of the transplant but upon request, the team did not publish her name, age and cause of injury nor the donor’s identity. The patient’s family desired the reason for her transplant to remain confidential. The Los Angeles Times reported that the patient “had no upper jaw, nose, cheeks or lower eyelids and was unable to eat, talk, smile, smell or breathe on her own.” The clinic’s dermatology and plastic surgery chair, Francis Papay, described the nine hours phase of the procedure: “We transferred the skin, all the facial muscles in the upper face and mid-face, the upper lip, all of the nose, most of the sinuses around the nose, the upper jaw including the teeth, the facial nerve.” Thereafter, another team spent three hours sewing the woman’s blood vessels to that of the donor’s face to restore blood circulation, making the graft a success.

The New York Times reported that “three partial face transplants have been performed since 2005, two in France and one in China, all using facial tissue from a dead donor with permission from their families.” “Only the forehead, upper eyelids, lower lip, lower teeth and jaw are hers, the rest of her face comes from a cadaver; she could not eat on her own or breathe without a hole in her windpipe. About 77 square inches of tissue were transplanted from the donor,” it further described the details of the medical marvel. The patient, however, must take lifetime immunosuppressive drugs, also called antirejection drugs, which do not guarantee success. The transplant team said that in case of failure, it would replace the part with a skin graft taken from her own body.

Dr. Bohdan Pomahac, a Brigham and Women’s Hospital surgeon praised the recent medical development. “There are patients who can benefit tremendously from this. It’s great that it happened,” he said.

Leading bioethicist Arthur Caplan of the University of Pennsylvania withheld judgment on the Cleveland transplant amid grave concerns on the post-operation results. “The biggest ethical problem is dealing with failure — if your face rejects. It would be a living hell. If your face is falling off and you can’t eat and you can’t breathe and you’re suffering in a terrible manner that can’t be reversed, you need to put on the table assistance in dying. There are patients who can benefit tremendously from this. It’s great that it happened,” he said.

Dr Alex Clarke, of the Royal Free Hospital had praised the Clinic for its contribution to medicine. “It is a real step forward for people who have severe disfigurement and this operation has been done by a team who have really prepared and worked towards this for a number of years. These transplants have proven that the technical difficulties can be overcome and psychologically the patients are doing well. They have all have reacted positively and have begun to do things they were not able to before. All the things people thought were barriers to this kind of operations have been overcome,” she said.

The first partial face transplant surgery on a living human was performed on Isabelle Dinoire on November 27 2005, when she was 38, by Professor Bernard Devauchelle, assisted by Professor Jean-Michel Dubernard in Amiens, France. Her Labrador dog mauled her in May 2005. A triangle of face tissue including the nose and mouth was taken from a brain-dead female donor and grafted onto the patient. Scientists elsewhere have performed scalp and ear transplants. However, the claim is the first for a mouth and nose transplant. Experts say the mouth and nose are the most difficult parts of the face to transplant.

In 2004, the same Cleveland Clinic, became the first institution to approve this surgery and test it on cadavers. In October 2006, surgeon Peter Butler at London‘s Royal Free Hospital in the UK was given permission by the NHS ethics board to carry out a full face transplant. His team will select four adult patients (children cannot be selected due to concerns over consent), with operations being carried out at six month intervals. In March 2008, the treatment of 30-year-old neurofibromatosis victim Pascal Coler of France ended after having received what his doctors call the worlds first successful full face transplant.

Ethical concerns, psychological impact, problems relating to immunosuppression and consequences of technical failure have prevented teams from performing face transplant operations in the past, even though it has been technically possible to carry out such procedures for years.

Mr Iain Hutchison, of Barts and the London Hospital, warned of several problems with face transplants, such as blood vessels in the donated tissue clotting and immunosuppressants failing or increasing the patient’s risk of cancer. He also pointed out ethical issues with the fact that the procedure requires a “beating heart donor”. The transplant is carried out while the donor is brain dead, but still alive by use of a ventilator.

According to Stephen Wigmore, chair of British Transplantation Society’s ethics committee, it is unknown to what extent facial expressions will function in the long term. He said that it is not certain whether a patient could be left worse off in the case of a face transplant failing.

Mr Michael Earley, a member of the Royal College of Surgeon‘s facial transplantation working party, commented that if successful, the transplant would be “a major breakthrough in facial reconstruction” and “a major step forward for the facially disfigured.”

In Wednesday’s conference, Siemionow said “we know that there are so many patients there in their homes where they are hiding from society because they are afraid to walk to the grocery stores, they are afraid to go the the street.” “Our patient was called names and was humiliated. We very much hope that for this very special group of patients there is a hope that someday they will be able to go comfortably from their houses and enjoy the things we take for granted,” she added.

In response to the medical breakthrough, a British medical group led by Royal Free Hospital’s lead surgeon Dr Peter Butler, said they will finish the world’s first full face transplant within a year. “We hope to make an announcement about a full-face operation in the next 12 months. This latest operation shows how facial transplantation can help a particular group of the most severely facially injured people. These are people who would otherwise live a terrible twilight life, shut away from public gaze,” he said.

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Sunday, December 5, 2004

SAN FRANCISCO –Shawn Fanning, the creator of Napster and a founder of Snocap, Inc., on Friday revealed his plans for a legal peer-to-peer file-sharing platform. Snocap has signed an agreement with Universal Music Group to make the company’s entire catalogue available through the new service. Financial terms of the deal were not disclosed.

According to Snocap’s press release, the platform will include a copyright management interface, which will allow content owners to control the distribution of their intellectual property among users. The service’s main competitor would be Apple‘s iTunes Music Store, which is currently the most widely used legal source of downloadable music.

Thursday, February 28, 2008

There were 6 games played in the National Hockey League on February 27, 2008. Colorado finishes their three-game road trip in eastern Canada against the Canucks, Minnesota tries to break a 4 game losing streak in an out-of-conference game against the Lightning, and the Maple Leafs try to pick up their fifth win in 6 games.

Sunday, February 11, 2007

Recent tests have shown that an inexpensive drug may be able to kill cancer cells in humans. Dichloroacetate, a drug generally used to treat rare metabolic disorders, has shown the potential to assist in the treatment of brain, lung, and breast cancers, researchers at the University of Alberta in Edmonton, Canada say.

Dr. Evangelos Michelakis of the University of Alberta in Edmonton, Canada found that that DCA causes tumor regressions in animals with human cancers. Testing showed that DCA attacked cancer cells but did not attack healthy cells.

The researchers and the Alberta Cancer Board and Capital Health do not advise the use of DCA to treat cancer yet, as clinical trials for the drugs use to treat cancer have not been performed yet.

Unlike healthy cells, cancerous cells do not convert food molecules into energy in the mitochondria. Instead, they rely on a process known as glycolysis, which takes place in the main body of the cell, while the mitochondria are “shut down”, researchers believe possibly due to the lack of oxygen supply to cells in the middle of a tumor.

This means that another key function of the mitochondria – to activate an abnormal cell’s self-destruct mechanism, apoptosis – is also blocked.

When Dichloroacetate (DCA) enters a cancer cell, it restarts the mitochondria which in turn activate apoptosis, and the cancerous cell destroys itself.

DCA is known to be relatively safe, although pain, numbness and gait disturbances may occur. The drug is also expected to be cheaper to manufacture than other drugs since there is no patent for it.

Friday, October 7, 2016

Following an accidental death at the closed Underwater World Singapore (UWS) aquarium in Sentosa on Tuesday, operations to relocate the facility’s animals have been suspended.

Phillip Chan, 62, the head diver of the defunct facility, was moving stingrays in preparation for transfer to another aquarium when one of them stung him in the chest. Singapore newspaper The New Paper reported no prior such stingray incident was known to have occurred in Singapore. Australian conservationist Steve Irwin died in a similar manner in 2006.

Following a call to the Singapore Civil Defense Force at 2:20 pm, Chan was found near the entrance of UWS, where attempts were made to resuscitate him via CPR. He was taken to Singapore General Hospital, where he died from his injuries. While Chan’s colleagues declined to comment to The New Paper, a staff member at Shangri-La’s Rasa Sentosa Resort & Spa, who witnessed Chan being taken away by ambulance, stated, “It all happened very quickly. The ambulance came and quickly left the premises. I’ve never seen such an incident happening here before.”

UWS operator Haw Par Corporation described Chan as a “veteran diver, aquarist and animal caregiver who had been caring for the aquatic animals at UWS since its opening in 1991”. Ten staff, including Chan, remained at UWS after its closure on June 27 to facilitate care for its animals until they could be suitably relocated. In addition to assisting the Ministry of Manpower’s (MOM) Occupational Safety and Health Inspectorate with their investigations, Haw Par has pledged Chan’s family “all possible support and assistance”. Due to Chan’s death, MOM has ordered the cessation of animal transfers from UWS while investigations are pending.

In an interview with The New Paper, Dr. Tan Heok Hui, an ichthyologist and Lee Kong Chian Natural History Museum operations officer, stated, “Stingrays attack when they feel threatened, cornered or alarmed. Sometimes, a stingray might feel threatened when someone accidentally steps on it. Stingrays have backward pointing barbs on the spine that have serrated edges. They don’t just cause physical pain, the toxins in the spine can also cause extreme discomfort. When a spine pierces human flesh, it breaks and releases toxins into the flesh.”

Stingray venom contains serotonin, a neurotransmitter that can induce severe muscle contractions. According to Dr Tan, “If a victim is hit in vital organs like the chest area, it may trigger a cardiac arrest, which could subsequently be fatal”. “Stingrays are not usually aggressive, and choose defensive methods to protect themselves. However, stingrays are still wild animals, and when provoked and left with no choice, they will defend themselves using their sting.”

In an interview with The New Paper at the time of UWS’ closure in June, Chan said of the animals he worked with, whom he described as his “band of friends”, “They are so quietly tame. […] We intend to find them the best homes and environment. The next time I see them, I might not recognise them any more but if I dive, they might recognise me.”

Chan’s work at UWS entailed diving into the tanks and feeding the animals whilst visitors took photos. In an interview at the time with The Straits Times, Chan stated, “I treat [the animals] like my babies.” Chan also related anecdotes where he was bitten by sharks who mistook him for fish, releasing him when they recognised their mistake, describing the animals as “gentle”. “Whenever I get in danger,” said Chan, “I just keep calm. I can overcome any danger by just being calm”.

MOM stated of Chan’s death, “The Ministry of Manpower was informed about an incident that took place at Underwater World Singapore Pte Ltd’s premises at Siloso Road on 4 October 2016. Officers from MOM’s Occupational Safety and Health Inspectorate responded to the scene immediately and commenced investigations. Preliminary findings indicate that a worker was pierced in his chest by the barb of a stingray while he was in the midst of transferring the stingray from its tank. He was conveyed to hospital where he subsequently succumbed to this injuries.^[sic] MOM has instructed the occupier to stop all activities associated with the transferring of sea animals. Investigations are ongoing.”